GTC Biotherapeutics (fka GTCB)

[DewDiligence]

Re: Heparin-antithrombin binding

This graphic may help illuminate the relationship between heparin and antithrombin in anticoagulation: #msg-24393520. (I posted the graphic to explain the MoA of a drug candidate from MNTA called M118.)

The concept in the graphic is easier to understand if you bear in mind that all heparin products—unfractionated heparin as well as “low molecular weight” heparins such as Lovenox—are mixtures of short- and long-chain saccharides.

p.s. MNTA (my second largest biotech position after GTCB) is up 65% from its low in November, so December has been a good month for me so far.