MNTA’s M118: FIIa vs FXa Binding This graphic shows why LMWH has less inhibition of thrombin (FIIa) than of FXa.
LMWH is a complex mixture of variable-length chains, of which some are capable of binding to FIIa and some aren’t. Relative to unfractionated heparin, fewer chains in LMWH are capable of binding to FIIa and thus LMWH provides anticoagulation mainly by inhibiting FXa.
M118 from MNTA is a proprietary mixture of short- and long-chain heparins that is designed from the ground up to have the binding qualities and reversibility of unfractionated heparin while retaining the predictability of response and lack of monitoring that are the hallmarks of LMWH.
This graphic is best viewed in conjunction with #msg-23010615, which shows the clotting cascade.
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