Jim, somebody needs to make a biotech dilution web site, on the lines of the 'mortgage lender implodometer' site. A couple of times I have tried to make a graph of market cap and stock price versus time for my biotechs. But it is hard to get the historical data on what the float was at various times in the past.
Anyway, it is facinating to see the stock price of a biotech (like Cortex) essentially flat for years, while the total market cap of the company increases due to dilution. Biotech is a race between dilution and clinical progress/partnerships. We tend to focus too much on the clinical progress and partnerships when that is only have of the story.
Of course the other way to view small cap biotechs is as non-expiring options on the potential success the pipeline. So maybe from that perspective dilution is the price you pay for having your option not expire.