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Re: bcblbrbm post# 4056

Monday, 06/04/2007 4:21:05 PM

Monday, June 04, 2007 4:21:05 PM

Post# of 12660
Would one or some of you please step up and tell the rest of us if you think that we really stand a better than 50-50 chance at showing stat sig at the interim look? If not, please take a shot at the percentage.
Thanks again, I am just trying to stay focused on the prize and the known path to it.


You tell me what assumptions you would like to make:

a) In the end are you expecting curves like 9901? Or like 9902a? Or the blend? (This impacts the odds in obvious ways)

b) Do you believe that the curve shape will remain the same as in 9901 and 2a - where the HR in the early part of the curve is very significantly less than the HR in the later portion? (This very significantly impacts the chance of success for the interim look - note that I looked at the TAX327 trial and it too showed a very linear death curve which would tend to imply a big HR later and a lower HR earlier.)

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