Biotech Values

[gofishmarko]

Re : DNDN

>>> Absolutely no immune response to a physiological antigen <<<


The anti-GMCSF ab response wasn't so bad. ;)

Only half-kidding about that part , but I agree that the MOA is MIA. Some tumors secrete GMCSF , and some people think GMCSF at the wrong time and place can promote a regulatory phenotype , so an anti-GMCSF response could be the proverbial pony in the crap pile. I would find that hilarious , if it turned out to be the case.

The DNDN stuff I've looked at reveals research that would get a person fired in any decent lab. Maybe they held back all the interesting stuff , like results for controls. The graphs of immune response seemed designed to confuse or hide something , or both.

That said , MOA is not important if the 3-yr survival results are anything close to being real , and I don't think they're smart enough to have pulled off a complete hoax.

The upreg of CD54 could be a hint of something , and if P11 shows significant effects on PSA velocity that could hint at something also. One reason I'd like to see it approved is because I think some smart researchers out there would figure out what's going on long before DNDN does.