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Re: iwfal post# 43738

Wednesday, 03/28/2007 11:38:17 AM

Wednesday, March 28, 2007 11:38:17 AM

Post# of 257275
AGIX - IMO the key factors going forward for 1067 are:

a) The one case of liver failure.

b) The fact that AZN doesn't have a diabetes program.

The analysts are making hay of the liver enzymes with lots of comparisons to Rezulin (diabetes drug pulled from the market due to liver failure) - but Rezulin had much greater incidence of elevated enzymes and it had 2 liver failures in smaller patient pop and undoubtedly a smaller time on drug. Is the liver failure a cause for concern? Yep. Is it remotely comparible to Rezulin - not really.

Clark

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