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Re: forztnt2 post# 232885

Saturday, 04/11/2026 4:14:26 PM

Saturday, April 11, 2026 4:14:26 PM

Post# of 233428
I picked just one phrase out of one Patent application and asked AI what it meant. Here's the reply -- showing just how little chance a non-scientist has in grasping the high level organic chemistry that LWLG engineers and chemists are working with.

"Donors with substituents giving high steric hindrance" refers to chemical species—often Lewis bases, nucleophiles, or ligands—that possess large, bulky groups attached near their active site (the atom with a lone pair or high electron density). These bulky groups, such as tert-butyl or mesityl, physically obstruct the active site, making it difficult for the donor to approach or bind to another molecule (an electrophile or metal center)

Got that?? Digging the patent moat deeper and wider.
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