Sunday, March 29, 2026 5:19:14 PM
Yes that's true though it appears Anavex are indeed about to do another trial so will eventually be in this same situation only with much more promising data already in hand than LLY had in hand with their phase 2.
As mentioned back in early 2021 LLYs phase 2 top line result was valued around $22 billion.
From chat gpt:
"Lilly’s initial top-line Phase 2 announcement was on January 11, 2021. Reuters reported the stock went up as much as 13%, and another same-day market note showed Lilly at $189.40, up $22.99, or 13.8% after the announcement.
Lilly’s 2020 10-K says it had 958,425,693 shares outstanding as of February 12, 2021. Using the quoted move from about $166.41 to $189.40, the implied market cap went from about $159.5 billion to about $181.5 billion. That is an increase of about $22.0 billion."
Admittedly some of that was excitement value - "The fuller March 2021 presentation/NEJM publication still showed the 32% slowing on iADRS, but the market reaction turned more skeptical once investors focused on the mixed secondary read-through and safety profile. Lilly itself highlighted consistency across cognition/function measures, but Reuters noted not all secondaries were statistically significant, and ARIA-E occurred in 27% of treated patients.
If you want the immediate Phase 2 market-implied value: ~$22B
If you want the more realistic value investors assigned to the actual, imperfect Phase 2 package before Phase 3 confirmed things: ~$10–15B"
As mentioned back in early 2021 LLYs phase 2 top line result was valued around $22 billion.
From chat gpt:
"Lilly’s initial top-line Phase 2 announcement was on January 11, 2021. Reuters reported the stock went up as much as 13%, and another same-day market note showed Lilly at $189.40, up $22.99, or 13.8% after the announcement.
Lilly’s 2020 10-K says it had 958,425,693 shares outstanding as of February 12, 2021. Using the quoted move from about $166.41 to $189.40, the implied market cap went from about $159.5 billion to about $181.5 billion. That is an increase of about $22.0 billion."
Admittedly some of that was excitement value - "The fuller March 2021 presentation/NEJM publication still showed the 32% slowing on iADRS, but the market reaction turned more skeptical once investors focused on the mixed secondary read-through and safety profile. Lilly itself highlighted consistency across cognition/function measures, but Reuters noted not all secondaries were statistically significant, and ARIA-E occurred in 27% of treated patients.
If you want the immediate Phase 2 market-implied value: ~$22B
If you want the more realistic value investors assigned to the actual, imperfect Phase 2 package before Phase 3 confirmed things: ~$10–15B"
Recent AVXL News
- Anavex Life Sciences Highlights New Scientific Findings on Shared Biology Between Autism and Alzheimer’s Disease • GlobeNewswire Inc. • 04/14/2026 11:30:00 AM
- Anavex Life Sciences to Present at the 25th Annual Needham Virtual Healthcare Conference • GlobeNewswire Inc. • 04/07/2026 11:30:00 AM
- Anavex withdraws EU approval filing for Alzheimer’s therapy • IH Market News • 03/30/2026 12:39:26 PM
- Anavex Life Sciences Provides Comprehensive Regulatory Update • GlobeNewswire Inc. • 03/30/2026 11:30:00 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 03/25/2026 08:06:00 PM
- Anavex withdraws EU marketing application for Alzheimer’s therapy blarcamesine • IH Market News • 03/25/2026 02:06:58 PM
- Anavex Life Sciences Provides Update on Regulatory Review in the EU for Blarcamesine to Treat Early Alzheimer’s Disease • GlobeNewswire Inc. • 03/25/2026 11:30:00 AM
- Anavex Life Sciences Presents New Data from its AD-004 Phase IIb/III Trial at AD/PD 2026 Conference Demonstrating Consistent Correlation Between the Treatment Effect of Oral Blarcamesine and Preservation of Brain Volume in Early Alzheimer’s Disease • GlobeNewswire Inc. • 03/23/2026 11:30:00 AM
- New Scientific Findings Highlight Hypothesis of Autophagy Failure as a Precursor of Amyloid Beta and Tau Pathology in Alzheimer’s Disease • GlobeNewswire Inc. • 03/20/2026 11:30:00 AM
- Anavex Life Sciences Presents Significant Treatment Effects of Blarcamesine in New Advanced Alpha-Synuclein Model of Parkinson’s Disease at AD/PD 2026 Conference • GlobeNewswire Inc. • 03/17/2026 11:30:00 AM
- Anavex Life Sciences to Present at the Citizens Life Sciences Conference • GlobeNewswire Inc. • 03/03/2026 12:30:00 PM
- Anavex Life Sciences to Present at the 46th TD Cowen Annual Health Care Conference • GlobeNewswire Inc. • 02/25/2026 12:30:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/25/2026 11:07:01 AM
- Anavex Life Sciences Appoints Seasoned Healthcare Leader to Board of Directors • GlobeNewswire Inc. • 02/23/2026 12:30:00 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 02/09/2026 09:40:27 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/09/2026 12:31:17 PM
- Anavex Life Sciences Reports Fiscal 2026 First Quarter Financial Results and Provides Business Update • GlobeNewswire Inc. • 02/09/2026 12:30:00 PM
- Anavex Life Sciences to Announce Fiscal 2026 First Quarter Financial Results on Monday, February 9, 2026 • GlobeNewswire Inc. • 02/03/2026 12:30:00 PM
- Anavex Joins ACCESS-AD, a Major Initiative Funded by the European Commission, Through the Clinical Evaluation of Blarcamesine as Part of a Precision Medicine Approach in Alzheimer’s Disease • GlobeNewswire Inc. • 01/13/2026 12:30:00 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/09/2026 10:26:26 PM
- Edelson Lechtzin LLP Announces an Investigation of Anavex Life Sciences Corp. (NASDAQ: AVXL) and Encourages Investors with Substantial Losses Contact the Firm • PR Newswire (US) • 01/09/2026 01:13:00 AM
- Anavex Life Sciences Appoints Senior Vice President Global Head of Neurology • GlobeNewswire Inc. • 01/08/2026 12:30:00 PM
- Anavex Life Sciences Receives FDA Feedback on Alzheimer’s Disease Program • GlobeNewswire Inc. • 01/06/2026 12:30:00 PM
- Anavex Life Sciences Submitted Request for EMA to Re-Examine Its Opinion • GlobeNewswire Inc. • 12/18/2025 12:30:00 PM
- Anavex Life Sciences Provides Update on Regulatory Review in the EU for Blarcamesine to Treat Early Alzheimer’s Disease • GlobeNewswire Inc. • 12/12/2025 09:05:00 PM
