Sangamo Biosciences Inc (SGMO)

[jondoeuk]

The Basecamp Research platform is called aiPGI and powered by EDEN evolutionary AI models (developed with NVIDIA). It ''learns the language of DNA and patterns of evolution.'' The models generate active insertion proteins tailored to target loci in the human genome using just the target sequence.

So rather than evolving or modifying natural recombinases, Basecamp's EDEN models are trained on massive evolutionary datasets to generate proteins with desired insertion activity. This aims to go beyond optimisation with the AI inventing new sequence solutions for insertion enzymes tailored to specific sites, potentially covering a much wider landscape of targets compared to manually (with directed evolution, rational design of recombinases, and/or protein engineering) evolved recombinases.