Sangamo Biosciences Inc (SGMO)

[jondoeuk]

Other companies, including Basecamp Research, are using AI to learn the rules for how recombinases target different sequences of DNA. Earlier this month, Basecamp announced its AI model could create new recombinases from scratch https://www.prnewswire.co.uk/news-releases/basecamp-research-launches-world-first-ai-models-for-programmable-gene-insertion-302657979.html https://www.biorxiv.org/content/10.64898/2026.01.12.699009v1.full

Seamless also uses AI, but to keep track of which mutations improve or hinder the activity of its enzymes, and feeds those results into a machine learning program that helps it pick out a library of enzymes for its next round of directed evolution. Since Seamless launched in 2023, it has sped up the process of evolving recombinases to target new sites from two years to under six months.