NorthWest Biotherapeutics Inc (NWBO)

[learningcurve2020]

>>Conclusions

Although direct evidence linking Crohn's disease or syphilis to improved GBM outcomes is currently limited, emerging research suggests that these conditions may modulate the immune system in ways that could theoretically influence GBM progression. Specifically, the chronic immune activation associated with both Crohn's disease and syphilis may enhance immune surveillance, potentially increasing the detection and elimination of tumor cells. Additionally, these immune alterations could modulate the tumor microenvironment through changes in microglial activation and cytokine expression, creating conditions that are less favorable for tumor growth. However, it is important to emphasize that these hypotheses remain speculative, and further research is necessary to clarify any potential causal relationships.

https://www.cureus.com/articles/428058-extremely-long-term-glioblastoma-survival-ten-years-a-possible-role-of-immune-modulation-from-pre-existing-diseases#!/