NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

On the TICE BCG, because of the shortage Merck started building a new plant about a decade ago. Since then other companies with other versions of BCG have stepped in around the world to fill the gap for BCG bladder cancer treatment and also for BCG vaccines.

Still, the IP in making DCVax-Direct with TICE BCG became more implanted. That IP lasts through about 2036.

The Merck plant will ramp to ultimately triple TICE BCG when it opens at the end of this year, if the proposed mystery backup to TICE BCG isn’t as good as TICE in helping make DCVax-Direct, I suspect it isn’t, and TICE BCG works better with the better timed and produced DCVax-Direct in new cancer trial trials (including some combination trials), I suspect it will, Merck won’t take ten years to build another TICE BCG plant — not even four years imo.

Then there are Dr. Bosch’s lipid inflammasome enhanced dendritic cells, where oxidized lipids, delivered via the CD14 receptor, can put a dendritic cell into a state of "Hyperactivation." That is almost assuredly hoing to massively enhance DCVax direct and L and the tech is a perfect candidate for a patent grant, if the application is granted it would out to 2040.