Fate Therapeutics Inc (FATE)

[NY1972]

Pharmas wasted billions on Tigit, LAG trying to revive exhausted T cells.

In late-stage solid tumors, many 4-1BB? cells are:

1. Chronically exhausted

They express:

PD-1

TIM-3

LAG-3

TIGIT

CTLA-4

low granzyme/perforin

These cells consume cytokines, occupy metabolic niches, and block CAR-T expansion.

2. Suppressive

A subset of 4-1BB? Tregs expands in stage 4 tumors.