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Sunday, 11/16/2025 10:40:56 AM

Sunday, November 16, 2025 10:40:56 AM

Post# of 516482
I’ve read the many comments submitted by posters since Friday’s debacle.

I only have a little to add but hope some will find it helpful.

My first comment relates to the “negative trend” in voting. Who disclosed this to the Anavex team? Was it one of the rapporteurs or a member of the committee? Since the vote was not yet final as of Friday there must have been someone who was hopeful that the situation could be salvaged. If the vote was not final, there may still have been hope that there's time for some negative voters to change their position.

This leads me to think that the mention of the FDA’s interest in the same press release as the EMA update was a prod by Anavex that the EMA voters need to be aware of the long-term consequences of a negative decision. Should they reject the Anavex solution they are opening themselves to being scooped as the first approvers of a world-changing therapy. Presently, they have approved two solutions that have serious side effects that few want to pay for or can afford. Do they want to be seen as followers later on after Blarcamesine is approved in the US? How will that be viewed in the countries that rely on them for leadership?

This is a “fool around and find out” moment for the EMA.

I hope they choose wisely.

Bill
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