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Re: Doc328 post# 507533

Thursday, 11/13/2025 3:19:07 PM

Thursday, November 13, 2025 3:19:07 PM

Post# of 517530
A couple of things:
1. Yes, drugged dropouts are high.
2. The trial was done under pandemic conditions, which is a mitigating factor. Though not completely: there were clearly tolerability issues. On the other hand: there is some evidence that tolerability itself was mitigated in the OLE.
3. Regardless of all the above, the ITT results should include the dropouts. (Unless Missling did some "modifications" but I doubt Jin would allow that.)
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