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Re: Hoskuld post# 504671

Monday, 10/27/2025 2:11:41 PM

Monday, October 27, 2025 2:11:41 PM

Post# of 517666

did they not run a 2nd trial because they thought the data would not confirm the original trial's findings?



Where is the logic in that that confirmatory second trial results would be poorer? With current titration practices, drop-outs would be expected to be lower. With patient eligibility criteria tightened to include more early stage patients, positive efficacy would likely increase. With larger patient numbers, the positive effect data would be expected to increase.
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