Anavex Life Sciences Corp (AVXL)

[falconer66a]

Am Working With My Oncologist

I hope you get better soon.

Thank you.

Presently, my only lymphoma symptom is anemia. The Waldenstrom’s macroglobulinemia oncocytes are located in my bone marrow, where they interfere with the production of oxygen-carrying red blood cells. Typically with WM, I have a low hematocrit, an RBC deficiency. I need to take one or two short naps during the day.

But I’m “self-medicating” with a supplement, neem leaf, that in a University of Ontario study showed remarkable cancer-suppressing effects. There are a number of chemicals in the leaf of the neem tree, Azadirachta indica, that the study definitively showed kill oncocytes (cancer cells) but have no effects on normal human cells. And, those chemicals have their oncolytic effects in minute nanogram concentrations. Of particular interest is nimbolide, which I believe is continuing to suppress my lymphoma.

I’ve been diagnosed with WM now for eight years, and all WM symptom metrics have remained at a non-progressing, almost prodromal baseline. No typical progression of the lymphoma yet.

Perhaps, because at my diagnosis, eight years ago, I searched the literature for information on my blood cancer. What I found were two things not embraced or mentioned by American oncology. I decided to experiment on myself.

First, of course, I checked to learn of potential toxicities and side effects. In the two modalities I wanted to try I found none. So, I began.

First, I discovered that an initial standard of care (SOC) treatment for WM in Germany is the taking of resveratrol, a healthful antioxidant in wine. But, I was aware of an even more beneficial enantiomer and started taking it, trans-resveratrol.

A few months later I discovered this University of Ontario paper:
https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/25221/19178

And, this paper:
https://pubmed.ncbi.nlm.nih.gov/25382610/

From the University of Onatrio study it appeared that the neem leaf chemical nimbolide, in nanogram (billionths of a gram) concentrations is the chemical entity yielding treatment efficacies against my B-cell lymphoma. So, I started popping a pill of neem leaf every day.

Then, last spring, to see if anything was happening, I terminated the neem leaf. For a few days, nothing changed. Then, one morning I wakened to find itchy spots, with red (blood) spot centers across my torso. I knew that these pruritic (itchy) skin patches are a symptom of progressing WM.

I immediately resumed my neem pills and within a week the blood-spotted itchy patches were gone.

The neem leaf supplement appears to be keeping my Waldenstrom’s macroglobulinemia in suppression. But, if it starts to progress, blarcamesine may then be available as a WM therapeutic, as implicated in the new Anavex patent application.