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Re: Hoskuld post# 502079

Friday, 10/03/2025 11:54:17 AM

Friday, October 03, 2025 11:54:17 AM

Post# of 517546
The most recently approved drug for ALZ, Lecanemab, was approved based on meeting the CDR-SB primary endpoint and plasma and amyloid-beta biomarkers. Blarcamesine's clinical trial measured ADAS Cog and ADCS-ADL as primary endpoints and CDR-SB as secondary, plus brain atrophy, Tau, and amyloid-beta. All stat. significant, but the ADCS-ADL achieved it outside of the 48 week period. Nonetheless, there's never been a better performing drug that has filed for approval with EMA.
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