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$MAJI (Exousia Pro inc) Eradicating the Root of Cancer: Targeted Therapy of Cancer Stem Cells via Exosoma

The speaker, CEO Mike Sheikh from Exousia Pro, Inc., proposes killing #Glioblastoma (GBM) by targeting its resistant cancer stem cells (CSCs), which cause 90% recurrence rates despite standard treatments like #temozolomide (TMZ) #chemotherapy and #radiation. These CSCs evade death due to the #MGMT #enzyme repairing TMZ-induced #DNA damage. His solution uses patented exosome technology: natural, #nanoscale vesicles (30-100 nm) derived from #mesenchymal stem cells, engineered to carry a genetic payload (shRNA) that silences the MGMT gene. The #exosomes are "decorated" with brain-homing peptides for precise targeting, enabling them to cross the blood-brain barrier (BBB), permeate brain tissue, and deliver the payload directly to CSCs via peripheral administration (e.g., subcutaneous injection or potentially inhalation). This sensitizes the CSCs to #TMZ, paralyzing their repair and proliferation mechanisms. In vitro results show the combination kills nearly 100% of CSCs at normal TMZ doses (3x efficacy boost) or even 100th doses, with some cell death observed without chemo. Preclinical mouse models (using humanized mice with implanted human GBM CSCs) demonstrate robust BBB penetration and functional delivery, aiming to eradicate the "root" CSCs and prevent relapse for long-term remission.

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