NorthWest Biotherapeutics Inc (NWBO)

[Galzus Research]

I dont’t know why people keep citing this 73 authors figure. It’s meaningless to the interpretation.

Yes, they agreed to be authors. Yes, that means they feel these data support the conclusion presented. It does not mean they think the trial was perfect, or the design/conduct/results unimpeachable. It does not mean that the study warrants instant practice change, in itself.

Look at the POLO trial for a prime example. Top flight, well-respected researchers generated a nominally successful trial with issues in the trial design that made it difficult to know who should actually get PARP inhibitors for gBRCA PDAC. OS not significantly improved.

The drug still got approved. It now languishes as a so-so option. The study authors are to a person respectable, excellent researchers who produced a study with challenges in interpretation due to its design. They still published it. That does not make the POLO approach right for every biomarker-positive patient.

And if DCvax’s JAMA study study was totally negative, those same 73 would have signed onto it. It’s challenged science done by good researchers.