NorthWest Biotherapeutics Inc (NWBO)

[exwannabe]

Yes EX because surgeons go out of their way to leave tumorous material behind with bad margins so patients don't survive ...

I guess you just do not understand GBM too well.

Upon diagnosis many patients will get a full resection. But many will not, getting either partials or biopsies only. Reason is obvious to most, if the cancer is entwined in significant portions of the brain it cannot be removed. Maybe only about 50% have full resections.

The NWBO P3 did not allow patients who were only going to have biopsies are partial resections. They only recruited if a full resection was planned. Now, that is fine for a randomized trial, they would still be comparing the same type patients. But when the P3 "lost" the comparator arm is was no longer a randomized trial, and was comparing to other trials. And those trials did allow patients with biopsies and partials.

And now look at the result subgroups on this. The comparison on "near total resection" patients was apples to apples (on this issue). And it showed no benefit. It was those with over 1cm^3 (?) of tumor left that showed the benefit. But these were very different populations between the arms. The -L despite having "significant" residue disease would still have far less than the partials and biopsies in the external arms.

I am sure this will go right over your head though.

What is stunning is longs cannot take a look from 20,000 ft. NWBO ran a randomized trial and patients randomized to -0L did no better than those randomized to placebo. Nobody will ever find a trial approved on the basis of such a trial. And yet, you invested knowing that.

Have a nice day.