NorthWest Biotherapeutics Inc (NWBO)

[dstock07734]

Have you read ASCO presentation page by page? Have you read the PR of the following?

NWBO is the only company on this planet that has the technology enabling dendritic cells to present hundreds of tumor-associated antigens to immune system. How many tumor-associate antigen can Provenge present to immune system? Only one!

The company has been releasing plenty news. It is just that you are not equipped with appropriate IQ to understand them. Truth hurts!

One of the key factors making GBM so difficult to treat is that it is an extremely heterogeneous tumor. “Accumulating evidence suggests that intratumor heterogeneity likely is the key to understanding treatment failure” in GBM (Sottoriva, PNAS, 2013). Another key challenge is that as GBM develops, it induces an immunosuppressive microenvironment which compounds the difficulty of mounting an effective immune response against the tumor – especially within the central nervous system, which is an immune privileged space behind the blood brain barrier.
DCVax-L is designed to address both of these key challenges.

As the Company previously reported, proteomic studies have demonstrated that a single tumor lysate sample contained tens of thousands of different peptides and, out of this pool, the dendritic cells selected, processed and presented over 600 different peptides (tumor targets) to T cells. T cell studies (TCR sequencing and T cell clonal expansion assays) analyzing the breadth and strength of T cell response following DCVax-L treatment have found extensive responses, including clonal expansion of up to 800 T cell clones at month 4 and up to 1200 T cell clones at month 8 in the samples studied. Each T cell clone focuses on a particular and distinct target. In individuals not being treated with the vaccine, only 2 – 20 new T cells clones are seen between month 4 and month 8.

The results of these proteomic, T cell and other studies provide support for what the Company believes to be the mechanism of action of DCVax-L: i.e., mobilizing a broad spectrum and strong de novo T cell response that addresses the extensive heterogeneity of GBM and overcomes the immunosuppressive microenvironment around the tumor.