Tuesday, December 24, 2024 9:38:45 AM
I agree with Mayomobile that we have entered partnership and buyout season now that blarcamesine is up for approval with the EMA.
I think that, more through happenstance than planning, we soon will enter an NDA process that will conclude on about the same timetable as the MAA process. This would be a favorable development, particularly as it may affect buyout offers.
But it's much more likely to me that a partnership deal would occur first, perhaps as soon as 1Q2025, but almost surely 1H2025. Anavex definitely wants one, the terms of a partnership compared to a buyout at this stage are going to be less contentious, and a partnership would strengthen our hand in any subsequent buyout scenario. The partnership may not be global; there could even be a couple of partnerships, e.g., US and ROW.
This strong possibility is now baked into share price dynamics, and it will drive a continuing bull move in AVXL -- particularly fueled by short covering. Institutional shorts will not want to wake up one morning to an Anavex with a BP partnership deal. Expect continuing short message board posts and Seeking Alpha articles, but also brace for false rumors about the company, the drug, and/or the approval process(es).
I am less concerned with our somewhat diminished cash hoard, because I think Missling will, if useful, sell shares into an elevated share price in the coming months. If there's a partnership, which is very likely, Anavex will be swimming in cash.
As for the buyout possibility, I don't think Anavex would make the first move -- first, because I still think they prefer independence and, second, because it would put them one down in any negotiations. Given the two massive AD markets we are targeting, collectively worth well over $50B in annual sales, only major BP players should apply.
Anavex will have the best understanding of whether their approval chances are more 3 to 4 percent or 99 percent when any buyout offer develops. Assuming as I do that it leans more to the latter, the company would want to avoid a deal before an approval, and they should have the legal and financial wherewithal to delay. (The counter strategy by a suitor would be to make an open market bear hug offer to shareholders at a very attractive price.)
At this stage I can't see a deal going through for less than hundreds of dollars per share, assuming that there remain strong prospects for drug approval. Of course, any deal before an approval will be cheaper than a deal after an approval.
Good times.
I think that, more through happenstance than planning, we soon will enter an NDA process that will conclude on about the same timetable as the MAA process. This would be a favorable development, particularly as it may affect buyout offers.
But it's much more likely to me that a partnership deal would occur first, perhaps as soon as 1Q2025, but almost surely 1H2025. Anavex definitely wants one, the terms of a partnership compared to a buyout at this stage are going to be less contentious, and a partnership would strengthen our hand in any subsequent buyout scenario. The partnership may not be global; there could even be a couple of partnerships, e.g., US and ROW.
This strong possibility is now baked into share price dynamics, and it will drive a continuing bull move in AVXL -- particularly fueled by short covering. Institutional shorts will not want to wake up one morning to an Anavex with a BP partnership deal. Expect continuing short message board posts and Seeking Alpha articles, but also brace for false rumors about the company, the drug, and/or the approval process(es).
I am less concerned with our somewhat diminished cash hoard, because I think Missling will, if useful, sell shares into an elevated share price in the coming months. If there's a partnership, which is very likely, Anavex will be swimming in cash.
As for the buyout possibility, I don't think Anavex would make the first move -- first, because I still think they prefer independence and, second, because it would put them one down in any negotiations. Given the two massive AD markets we are targeting, collectively worth well over $50B in annual sales, only major BP players should apply.
Anavex will have the best understanding of whether their approval chances are more 3 to 4 percent or 99 percent when any buyout offer develops. Assuming as I do that it leans more to the latter, the company would want to avoid a deal before an approval, and they should have the legal and financial wherewithal to delay. (The counter strategy by a suitor would be to make an open market bear hug offer to shareholders at a very attractive price.)
At this stage I can't see a deal going through for less than hundreds of dollars per share, assuming that there remain strong prospects for drug approval. Of course, any deal before an approval will be cheaper than a deal after an approval.
Good times.
Recent AVXL News
- Anavex Life Sciences to Present at the 25th Annual Needham Virtual Healthcare Conference • GlobeNewswire Inc. • 04/07/2026 11:30:00 AM
- Anavex withdraws EU approval filing for Alzheimer’s therapy • IH Market News • 03/30/2026 12:39:26 PM
- Anavex Life Sciences Provides Comprehensive Regulatory Update • GlobeNewswire Inc. • 03/30/2026 11:30:00 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 03/25/2026 08:06:00 PM
- Anavex withdraws EU marketing application for Alzheimer’s therapy blarcamesine • IH Market News • 03/25/2026 02:06:58 PM
- Anavex Life Sciences Provides Update on Regulatory Review in the EU for Blarcamesine to Treat Early Alzheimer’s Disease • GlobeNewswire Inc. • 03/25/2026 11:30:00 AM
- Anavex Life Sciences Presents New Data from its AD-004 Phase IIb/III Trial at AD/PD 2026 Conference Demonstrating Consistent Correlation Between the Treatment Effect of Oral Blarcamesine and Preservation of Brain Volume in Early Alzheimer’s Disease • GlobeNewswire Inc. • 03/23/2026 11:30:00 AM
- New Scientific Findings Highlight Hypothesis of Autophagy Failure as a Precursor of Amyloid Beta and Tau Pathology in Alzheimer’s Disease • GlobeNewswire Inc. • 03/20/2026 11:30:00 AM
- Anavex Life Sciences Presents Significant Treatment Effects of Blarcamesine in New Advanced Alpha-Synuclein Model of Parkinson’s Disease at AD/PD 2026 Conference • GlobeNewswire Inc. • 03/17/2026 11:30:00 AM
- Anavex Life Sciences to Present at the Citizens Life Sciences Conference • GlobeNewswire Inc. • 03/03/2026 12:30:00 PM
- Anavex Life Sciences to Present at the 46th TD Cowen Annual Health Care Conference • GlobeNewswire Inc. • 02/25/2026 12:30:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/25/2026 11:07:01 AM
- Anavex Life Sciences Appoints Seasoned Healthcare Leader to Board of Directors • GlobeNewswire Inc. • 02/23/2026 12:30:00 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 02/09/2026 09:40:27 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/09/2026 12:31:17 PM
- Anavex Life Sciences Reports Fiscal 2026 First Quarter Financial Results and Provides Business Update • GlobeNewswire Inc. • 02/09/2026 12:30:00 PM
- Anavex Life Sciences to Announce Fiscal 2026 First Quarter Financial Results on Monday, February 9, 2026 • GlobeNewswire Inc. • 02/03/2026 12:30:00 PM
- Anavex Joins ACCESS-AD, a Major Initiative Funded by the European Commission, Through the Clinical Evaluation of Blarcamesine as Part of a Precision Medicine Approach in Alzheimer’s Disease • GlobeNewswire Inc. • 01/13/2026 12:30:00 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/09/2026 10:26:26 PM
- Edelson Lechtzin LLP Announces an Investigation of Anavex Life Sciences Corp. (NASDAQ: AVXL) and Encourages Investors with Substantial Losses Contact the Firm • PR Newswire (US) • 01/09/2026 01:13:00 AM
- Anavex Life Sciences Appoints Senior Vice President Global Head of Neurology • GlobeNewswire Inc. • 01/08/2026 12:30:00 PM
- Anavex Life Sciences Receives FDA Feedback on Alzheimer’s Disease Program • GlobeNewswire Inc. • 01/06/2026 12:30:00 PM
- Anavex Life Sciences Submitted Request for EMA to Re-Examine Its Opinion • GlobeNewswire Inc. • 12/18/2025 12:30:00 PM
- Anavex Life Sciences Provides Update on Regulatory Review in the EU for Blarcamesine to Treat Early Alzheimer’s Disease • GlobeNewswire Inc. • 12/12/2025 09:05:00 PM
- Anavex Life Sciences to Present Oral Blarcamesine Data at the 18th Clinical Trials on Alzheimer’s Disease (CTAD) Conference • GlobeNewswire Inc. • 11/26/2025 12:30:00 PM
