Anavex Life Sciences Corp (AVXL)

[Hosai]

"You might make the case that they didn't know so they didn't go all in. But they represented to us (buyers of shares) that they were committed to succeeded - not that they were semi-committed and hedging their bets."

Every company trying to develop an early AD drug is to some degree hedging their bets because the odds are stacked against them. Nearly all will find their drug doesn't work. Hence only a couple of new AD drugs in EMA in last few decades. Hence why other pre-revenue companies such as Annovis, Biovie and Alzheon all go for similar smaller size trials. (obv Annovis and Bivi both then had additional issues with theirs). Sava are an exception when it comes to their size of trials and being pre-revenue imo.
Companies that get too low on cash run into big troubles as Baked Lasagne pointed out. Dr Missling has to balance out these factors, they obv also didn't foresee the higher dropout rate covid would exacerbate.