Wednesday, November 13, 2024 4:34:04 PM
I'm not suggesting anything I posted simply because i found it a curious coincidence that the ark bio drug had a new trial listing for a QTC trial that was posted within a week of ENTA's posting their QTC trial. I honestly didn't know the current status of ziresovir, and still don't really ark is private and not much out there. However I don't think you plan a QTc unless you are hoping to progress into a phase 3, and they are a competitor, so worth keeping an eye on IMO (along w Shionogi L inhibitor which is going to have challenge data this quarter). Ark lists their drug as completing phase 2 ex china so I don't think this is any big surprise and I actually don't think this is at all related to the weakness in ENTA. If anything if ARK is having discussions w FDA regarding a phase 3 might be nice for ENTA - let them hash it out and ENTA can then align w FDA faster if they progress into phase 3 as well
I added some detail from their phase 3 trial bc the authors echo ENTA management regarding limitations of their drug and the probable need for further data to confirm a clinically meaningful effect - something an editorial in NEJM mentions as well.
This trial is also a good frame of reference for virology (.6 log difference relative to PBO). On the clinical side will be difficult to show much but you never know. Ark did show shorter NICU stay on drug with an N=12 admitted to NICU so it's possible something can come up even though the ENTA trial is much smaller (Ark notably had nothing on oxygen requirements, hospital stay, etc. so I assume there was no difference relative to PBO)
I added some detail from their phase 3 trial bc the authors echo ENTA management regarding limitations of their drug and the probable need for further data to confirm a clinically meaningful effect - something an editorial in NEJM mentions as well.
This trial is also a good frame of reference for virology (.6 log difference relative to PBO). On the clinical side will be difficult to show much but you never know. Ark did show shorter NICU stay on drug with an N=12 admitted to NICU so it's possible something can come up even though the ENTA trial is much smaller (Ark notably had nothing on oxygen requirements, hospital stay, etc. so I assume there was no difference relative to PBO)
Recent ENTA News
- Enanta Pharmaceuticals Announces First Participant Dosed in Phase 1 Clinical Trial of EDP-978, an Oral, Once-Daily KIT Inhibitor, in Development for the Treatment of Urticaria • Business Wire • 04/13/2026 11:00:00 AM
- Enanta Pharmaceuticals to Present Data for Zelicapavir, an Oral, Once-Daily, N-Protein Inhibitor, in Development for the Treatment of Respiratory Syncytial Virus, at ESCMID Global 2026 • Business Wire • 04/07/2026 11:00:00 AM
- Enanta Pharmaceuticals to Present Data for its STAT6 Inhibitor Program at IMMUNOLOGY2026TM, the Annual Meeting of the American Association of Immunologists (AAI) • Business Wire • 03/30/2026 11:00:00 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 03/26/2026 12:00:07 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 03/13/2026 08:20:56 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 03/13/2026 08:18:09 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 03/13/2026 08:17:04 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 03/13/2026 08:14:14 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 03/12/2026 08:05:29 PM
- Enanta Pharmaceuticals to Present at The Citizens Life Sciences Conference • Business Wire • 03/03/2026 12:00:00 PM
- Form EFFECT - Notice of Effectiveness • Edgar (US Regulatory) • 02/23/2026 05:15:10 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/13/2026 09:33:34 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/13/2026 09:31:44 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/13/2026 09:29:51 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/13/2026 09:28:45 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/13/2026 09:27:26 PM
- Form S-3 - Registration statement under Securities Act of 1933 • Edgar (US Regulatory) • 02/11/2026 09:43:43 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 02/11/2026 09:00:44 PM
- Enanta Pharmaceuticals to Present Preclinical Data for EDP-978, its KIT Inhibitor in Development for the Treatment of Type 2 Immune Diseases, at the 2026 AAAAI Annual Meeting • Business Wire • 02/10/2026 12:00:00 PM
- Enanta Pharmaceuticals Reports Financial Results for its Fiscal First Quarter Ended December 31, 2025 • Business Wire • 02/09/2026 09:01:00 PM
- Form DEFA14A - Additional definitive proxy soliciting materials and Rule 14(a)(12) material • Edgar (US Regulatory) • 01/26/2026 09:10:39 PM
- Form DEF 14A - Other definitive proxy statements • Edgar (US Regulatory) • 01/26/2026 09:05:32 PM
- Form SCHEDULE 13G/A - Statement of Beneficial Ownership by Certain Investors: [Amend] • Edgar (US Regulatory) • 01/20/2026 09:42:25 PM
