NorthWest Biotherapeutics Inc (NWBO)

[GoodGuyBill]

The results were spectacular in comparison to ALL other GBM treatment/trial during the last 20/30 years (and with poly-iclc + pdl1 + dcvax). What anyone "expected" from a blinded trial was speculation and no reason to hold NWBO accountable for those speculative estimates. The timing of the trail was too damn slow due to pseudo-progression and having to allow regulatory agencies to update their review process to accommodate new bios like DCVAX. Of course, there were likely reasons due to management's inefficiency. Hindsight is 2020.

1 yes they did complete the trial but way later than most here predicted. Results were solid but not 'spectacular' at median nearly 3 month improvement in OS. 13% 5 year survival better than double accepted averages - very good but far lower than what was expected on this board. I regularly got roasted for posting 20%-25% 5 year survival

I really don't think it mattered how it was handled. Wall-street would have found a way to destroy the stock if not that day, soon after. That doesn't mean management could not have done things differently. Without a cop on the wall-street beat and no consequences to resulting fraud and malfeasance,I won't lay the complete blame on management. Hell, they clearly documented fraud and manipulation in detail... still nothing is done yet even though the judge did agree that NWBO adequately proved its point... and spoofing is still occurring!

2the did release tld at NYAS but was handled very poorly by nwbo PR department. Should have had a PR touting a couple good items as summary tld with more to come with full paper - they did not and shareholders suffered

It was my understanding that the production unit was redesigned and was undergoing initial testing months ago. So it isn't complete but it works. Lots of testing to go and then validation by the appropriate authorities. NWBO has a viable product to automate DCVAx product.

3 flaskworks is hardly a done deal as at asm was still in design and testing mode - submission is based on manual method which imo is fine for now

Yes, it took longer than anyone expected to get to the finish line. The time between p3 completion and the Journal write-up along with the time between the the p3 completion and SAP/MAA submission was insanely long. But we are here. Though the buck stops with management, I don't think LP was sitting on her thumbs watching people die. I don't think LP was slow to answer questions for the hell of it because of incompetence, laziness or indifference. Much of the delay, and I speculate here, had to do with DCVAX requiring changes in how the RAs review it which had to be reflected in the SAP. Any time a disruptive product comes on the scene, new processes need to forged which takes time to understand and implement. I do understand you frustration here. You'd be more frustrated if they made a serious error and had to start over again.

5 they did eventually get to the finish line but imo years late. Data lock in 2020 yet SAP took way long and only 1 submission by end of 2023, may get 1 approval in 2024(I hope) but could take into 2025 (this on MHRA I believe unless nwbo is slow on answering questions) in 2015 nwbo was listed on NASDAQ worth 1 billion in market cap with under 100 millions shares outstanding. Now on otc, 1.2 billion shares and mc of 350 million. Don't think they are going to bankrupt any one nwbo has made it but they are the one in financial difficulties

This is section I couldn't disagree with you more. I question, with the utmost of respect, how one could look at what NWBO management has done and not give it its due props. But I do understand your frustration and experience it myself from time to time.

To me this does not seem like great management but to each their own