Tuesday, May 07, 2024 6:34:32 PM
Assuming the absorption of edp-323 is comparable to edp-938 you are looking at several orders of magnitude higher multiples of virologic inhibition with the newer RSV candidate since it has been described as having much greater potency than 938 (picomolar and subnanomolar vs nanomolar). Dose of 938 is 800mg a day.
I'm assuming this is why this question was asked. I kind of felt the company may be wasting resources on yet another RSV drug since the patients that would benefit from a combination of the two would tough to tease out, but now I am starting to get why they continued development - they were pretty far along anyway, it might actually be better based on this dosing and profile, and you want to stay a step ahead of competition.
same analyst asked this:
I think she was referring to the trifluoral group on paxlovid. I haven't followed the PFE calls and had no idea they had been so specific about the patent case with analysts in the past. I can't really speak to this at all - perahps one of the lawyers can chime in - but it seems poor form IMO to comment so specifically on ongoing litigation. I did google the term and found this referencing the patent:
https://www.linkedin.com/pulse/wondering-what-pfizer-wants-specifically-enumerated
So seems if the ENTA patent holds up it does indeed cover fluoro/ trifluoro groups
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