My take on the GLP1's:
On Mounjaro I lost 23% in 6 months. (Over 260 to under 200)
My guess is the SE profile would cause 1/3rd of people to drop out.
I'm a guy that has always loved to eat and cook. But I think that six months on Mounjaro has changed my eating habits. I am gaining some weight but much slower than I expected.
Because of the long half-life of Mounjaro, you need fewer doses than the administration directions call for. After some experimentation I was still losing weight with one shot per month. I suspect even that could be longer. The SE profile is bad enough that you really do not want more doses even when you seriously want to lose more.
When I return from vacation in March, I will re-evaluate my weight and set new goals.
It is not certain that I will need to take Mounjaro again. I might have the tools (behavioral modification) to lose weight without it. I will NOT hesitate to use it again if I need it. But I will be surprised if I am as dependent on it as I was the first six months.
It is astonishing what foolish things one can temporarily believe if one thinks too long alone ... where it is often impossible to bring one's ideas to a conclusive test either formal or experimental. J.M. Keynes