It can and will. The AD TLR is an excellent example: 45% difference in rate of dementia increase was very, very clear. FUD followed and continues to follow. p=0.0001 with respect to brain volume loss (in 2-73 treatment group's favor) but of course FUD has follow that, too.
FUD is not a real thing - it is to facts what derivatives are to equity. FUD has no impact on the FDA - the FDA is bound to follow the facts - but it does affect the emotions of investors and FUD can be ginned up based on absolutely nothing and still have effect. When Excellence TLR comes out then there will be FUD, regardless of how good the results are.
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