Biotech Values

[Mufaso]

Dew- I’m not certain that Mounjaro is worse than Wegovy/Ozempic when it comes to muscle loss.

That’s because these drugs (Mounjaro more so than Ozempic) cause loss of lean muscle mass as well as fat.

From the same article I reference in my previous post:
https://www.nbcnews.com/health/health-news/weight-loss-drugs-muscle-loss-rcna84936

Here is some data in the article from the Wegovy trial saying 40% of the weight loss was Muscle mass.

A 2021 clinical trial that tested the weight loss effects of Wegovy found that while about 40% of the weight people lost tended to be lean mass, including muscle, at the end of 68 weeks, people who took the drug had a lower risk of heart disease and better physical function compared to a placebo group.

Here is some data from a Mounjaro trial saying the muscle loss was only 25%:

Studies showed similar results for the drug tirzepatide, which is sold under the brand name Mounjaro. In a phase 3 clinical trial, “a reduction in lean mass was reported at a similar rate as what is seen in lifestyle-based treatments for obesity,” Jessica Thompson, a spokesperson for tirzepatide-maker Eli Lilly, said in an emailed statement.

Note that the article said that weight reduction from any intervention was about one-third of the weight we lost was lean mass making Mounjaro possibly better than old fashioned dieting in this regard.

A new analysis of data from the same trial found that after 72 weeks of taking the drug, about 25% of the weight participants lost was lean mass. However, the participants had an overall healthier body composition. Aronne, who worked on the trial, presented the findings this week at the European Congress on Obesity in Dublin

Disclaimers about the follies of comparing deferent trials aside, I would be very interested in any data you have that shows that semiglutide is better than tirzepatide for muscle mass retention or any other thoughts you have here.