NorthWest Biotherapeutics Inc (NWBO)

[dstock07734]

Doc,

From just one specific type of tumor, there are total over 38k peptides eluted from pulsed DCVax-L related to both MHC Class 1&2. In industry, there are no such sophisticated software system to deal with the amount of data of this magnitude. NWBO will need newly designed software systems to tackle all solid tumors. Do you think NWBO or BPs having the resources and will to design such a platform software? This is the type of infrastructure work that the government can play a perfect role. In the case of NWBO, we have to be bold to use our imagination. It is all because of the government involvement that the progress has been slow in the past two or three years. It seems to me that NWBO is waiting for the government to get its job done. Take a look at the JAMA paper. There was only one new reference introduced in the JAMA paper after the data lock. It was the FDA document on ECA.



Here are the peptides I took from Dr. Bosch's slide. If anyone has interest, google some of them to see if they all are available in the public domain.

Peptides MHC Class 1
DAVTYTEHAK
TPFGAYGGLLK
KTQDQISNIK
WNFPSPFYR
QVVNIPSFIVR
AVGPASILK
SSHNLAVHR
EPAAPVSIQR
EVTFVPGLYK
DTPGFIVNR
ETLPAEQDLTTK
ESYEVSLTQK
DVSPFDHSR
EAVRPGVLR
GVFHOTVSR
GTLEQWIEK
KLYDIIJVAK
KAHLGTALK
EAYDRDFLAR
ESILGGVLK
DSFPWEVPK
LSYNTASNK
VPAPFKPITR
YGFYTHVFR
DVFEAFYKK


Peptides MHC Class 2

AM[OX]EGIFIKPSVEPSAGHDEL
EQLGPVTQEFIIVDNLEKETEGLR
TVETRDGQVINETSQHHDDLE
LVPQQLAH
TETQEKNPLPSKETIEQEK
PGVTVKDVNQQEFVR
VSEADSSNADVWTK
DGQVINETSQHHDDLE
VEYGFQVK
WLHPNYSQV0IGLIK
LVDKFLEDJKK
AQLGGPEAAKSDETAAK
KVESLQEEIAFLKK
DIGFIKLD
FDHVITNM[OX]NNNYEPR
RVVNFIYVFHTLGQYFQKLGR
ESKKEDLVFIFWAPESAPLK
DPG1VANKKEEEDLAK
YDLDFKSPDDPSR
FLPSELRDEH
IEDGFSLK
ILTLTYVDKLIDDVHR