Biotech Values

[DewDiligence]

Re: LLY’s Retatrutide safety

[Triple-agonist drugs such as LLY’s Retatrutide] might be okay for weight loss because many patients will only use the medications for a modest time period then come off once they have lost a target amount of weight.

I’m inclined to concur with Mufaso’s viewpoint in #msg-172230478 that weight-loss drugs will need to be taken chronically to maintain lost weight.

…I don't know if titration combined with antiemetics etc can address a good chunk of the GI tox.

They probably can to a degree; however, titration is unlikely to help with arrhythmia and other cardiovascular side effects such as long-QT (which was observed in one patient in LLY’s trial and was deemed to be drug-related).