I look at all of the weight loss drugs that include a GLP-1 MOA as being necessary long term to keep the weight off. The simple theory is they work by suppressing appetite. If you go off them, you no longer suppress appetite and gain the weight back. Tolerability and whether you inject or not will be factors. IF you can tolerate an injectable "triple-g" (GLP-1, GIP and Glucagon) , you may use it to initially lose the weight and go on an oral to keep it off.
WRT Nash- yes there will be a need for long term drugs as well but I personally looking at the compounds containing GLP-1's as either maintenance or prevention. These compounds have shown little or no effect on fibrosis or inflammation although they do reduce liver fat which is thought to cause NASH in the the first place. So they may actually displace NASH drugs (e.g. ones from MDGL/AKRO/ENBT/VKTX) after NASH is resolved.
"People are best convinced by reasons they discover themselves"
