Prior to Marnix Bosch's ( CTO-NWBO) 6/3/23 ASCO presentation(lecture and slides) AVC (alphavestcapital.com) pointed out that the LIAU-UCLA-SPORE combination trial data showed that all CIs (checkpoint inhibitors) are more efficacious when dosed in combination with DCVax-L, and that some CIs do not work at all without DC VAX L. MRK's Keytruda( a CI with $21 billion in '22 revenues) is a good example. Keytruda as a mono therapy proved in five clinical trials that it did not increase efficacy, compared to SOC, in GBM. But when dosed in combination with DC VAX L , there was impressive efficacy .
There is now an update to the preliminary results for the $NWBO UCLA DCVax-L + Poly-ICLC Combo trial.
In Oct 2022 the slide deck was updated for Dr Liau's presentation. The KM Curve now shows a ~50% Overall Survival now approaching 10 YEARS. Pretty phenomenal stuff! pic.twitter.com/bNIx81pZGm
But on 6/3/23 at ASCO, Marnix Bosch presented data showing that DC VAX L is a process that can direct the immune system response to targets in all diseases, not just all solid tumor cancers. From conversations with our associates in Big Biotech and Pharma , they are shocked because they do not know how to do what NWBO has done .They know their portfolio of drugs will perform better when dosed with DC VAX L . Their attempts to replicate the manufacturing of DC VAX L have come up short . Plus they do not know how to get around the patent moat. They are left with attempting to buy NWBO, or invest in partnerships which will license them the rights to have access to the DC VAX L technology. What strategic moves are afoot?
"Dr. Bosch: „If you use a lysate from another tumor you get new antigens that are more appropriate to that particular tumor.“
Means AGNOSTIC."
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IHUB POST 600072 :
"June 3 , 2023 @ ASCO - NWBO's MOA REVEAL DAY- BOSCH DESCRIBES HOW DC VAX L WORKS - A NEW MEDICINE PLATFORM THAT WILL CHANGE HEALTHCARE .
ATL:"This MOA is not just specific to the brain, but should work for every organ in the human body."
BRIGHT BOY:" DCVax-L which provides the world of medicine the ability to DIRECT THE IMMUNE SYSTEM and thereby TARGET ALL DISEASES !!!!!!! In simple terms, DCVax-L is able to identify antigens, which in a perfect system, ARE NOT SUPPOSED TO BE THERE !!!! AND GET RID OF THEM!!!!!!!" "
ae kusterer Re: None Friday, June 09, 2023 10:46:24 AM Post# of 600166 Go June 3 , 2023 @ ASCO - NWBO's MOA REVEAL DAY- BOSCH DESCRIBES HOW DC VAX L WORKS - A NEW MEDICINE PLATFORM THAT WILL CHANGE HEALTHCARE .
ATL:"This MOA is not just specific to the brain, but should work for every organ in the human body."
BRIGHT BOY:" DCVax-L which provides the world of medicine the ability to DIRECT THE IMMUNE SYSTEM and thereby TARGET ALL DISEASES !!!!!!! In simple terms, DCVax-L is able to identify antigens, which in a perfect system, ARE NOT SUPPOSED TO BE THERE !!!! AND GET RID OF THEM!!!!!!!"
Post# 600033 of 600038 https://nwbio.com/ ( 6/3/23 slides and Bosch audio
SALIENT INSIGHT # 1 :
ATLnsider
Re: dmb2 post# 599782
Thursday, June 08, 2023 12:53:38 PM
Post# 599798 of 600033 dmb2, are you completely ruling out the possibility of the regulatory authorities approving DCVax-L on a tissue agnostic basis now, because of: (1) its non-toxic and excellent safety record. As of result, it will not harm cancer patients, but it probably will benefit most cancer patients; (2) it’s mechanism of action (MOA) of using the patient’s own dendritic cells, pulsed with the patient’s own tumor lysate (regardless of which organ(s) the tumor(s) is/are located), to activate T Cells to find, destroy and continue to fight the cancer tumor(s). This MOA is not just specific to the brain, but should work for every organ in the human body.
Then, require NWBio to complete post-approval Phase IV, confirmatory basket trials to validate the efficacy results, and to keep the tissue-agnostic approvals?
SALIENT INSIGHT # 2:
Bright Boy
Re: SkyLimit2022 post# 599901
Thursday, June 08, 2023 5:54:09 PM
Post# 599910 of 600034 To dovetail into your post:
Bright Boy
Re: attilathehunt post# 599819
Thursday, June 08, 2023 2:42:24 PM
Post# 599831 of 599870 So I'm going to go out on a limb here in my following comments, but I believe it's time and I believe the scientific/medical community is beginning to recognize that Northwest and it's brilliant team from Alton Boynton, Linda Powers, Dr. Bosch, Allen Turner( former NWBO employee), Dr. Linda Liau and her UCLA team, my friend that is truly a legend in the biotech world and everyone else involved in the development, discovery and understanding of the technology that drives the process that is DCVax-L , has provided the world of medicine with the ability to DIRECT THE IMMUNE SYSTEM and thereby TARGET ALL DISEASES!!!!!
In simple terms, DCVax-L is able to identify antigens, which in a perfect system, ARE NOT SUPPOSED TO BE THERE !!!! AND GET RID OF THEM!!!!!!!
AND Yes!!! You already know what this means !!! DCVax-L represents the platform technology that is a general application for all diseases !!!!!
Gregory Zivic, MD 4,274 Tweets See new Tweets Gregory Zivic, MD @metacollectiveG Follows you Artist/Emergency Physician/Manufacturing Engineer/Investor in NWBO Co-owner META Collective Media, Sailor, Captain SV Catsulo. Not an investment advisor. At all ArtistUnited Statesfineartamerica.com/profiles/grego…Joined December 2015 735 Following 1,546 Followers Followed by Bio99, Steven, and 139 others you follow Tweets Replies Media Likes Gregory Zivic, MD’s Tweets Gregory Zivic, MD @metacollectiveG · Jun 4 $NWBO next up; external controls. The controversy with this is hyperbole. The FDA is not going to ignore reality because those who stand to lose (be it BP or clinical researchers going down the wrong rabbit hole) are yelping. The safety is beyond compare and this is quite simple: Gregory Zivic, MD @metacollectiveG · Jun 4 $NWBO removing trials that some might believe add to bias based on patient characteristics had no effect on the analysis. Jealous researchers/BP don’t share IPD. Co. asked for IPD on all these studies. All refused. One of the Physicians lied to me directly saying he wasn’t asked. Gregory Zivic, MD @metacollectiveG · Jun 4 1/2 $NWBO Dr. Bosch’s presentation was a quiet K-Boom! In my opinion regarding T cell recruitment, activation, etc. But in particular one needs to comprehend T cell exhaustion in Cancers and in chronic viral infections (age and kill us). The clonal expansion found with DCVax Gregory Zivic, MD @metacollectiveG · Jun 4 $NWBO The “newly expanded” T cell clones I find particularly interesting. T Cell dysfunction and exhaustion cannot be overcome by PD-1 inhibition or Car-T (Car T cells themselves become exhausted and why this therapy has it’s drawbacks) Gregory Zivic, MD @metacollectiveG · Jun 4 2/2 $NWBO Also important was the finding that other Cancer antigens not previously found in GBM were found in the DCs after pulsing with Lysate. Also, viral antigens present. None of these have formally been found on GBM tumors before. Gregory Zivic, MD @metacollectiveG · Jun 4 $NWBO If anyone’s incapable of comprehending this take away one thing; what’s being shown here is the pivot toward how ALL disease will be treated and cured; all solid tumors, blood cancers, autoimmunity, viruses… incredible. Brilliance. https://nwbio.com/wp-content/uploads/NWBT_ASCO_slides_06032022_FINAL.pdf
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