AI
Friday, May 05, 2023 9:13:39 PM
Your assertions are verifiably false. PFS did not not fail as subsequently proven by the OS data. The PFS data were contaminated and therefore the investigators could not use the inaccurate PFS data as a reliable surrogate predictor of OS. Instead, they had to wait for actual OS data.
Oncologists always attempt to measure and predict PFS as they should.
OS is the ultimate standard, but you cannot wait until death to begin evaluating whether a cancer drug is efficacious. The physician must evaluate a patient’s response and try to determine whether the treatment is helping.
Today, doctors have better methods for measuring progression, particularly when studying immunotherapy agents which are still relatively new as the emerging field of cell-based science is leading to rapid changes in the understanding of how cancer can be assessed and treated.
The P3 for the DCVax-L cell-based technology spanned many years. If the trial were designed and commenced in 2023, the investigators would appropriately attempt to measure progression and predict survival using the best methods and most current medical knowledge available in 2023, as any cancer researcher would.
Interview with Linda M. Liau, MD, PhD, author of Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma, in a podcast with @JackWestMD. https://t.co/POEeEg5cVz
— JAMA Oncology (@JAMAOnc) November 18, 2022
This study found that autologous tumor lystate-loaded dendritic cell vaccination plus standard of care (SOC) was associated with improved survival in both newly diagnosed & recurrent glioblastoma compared with matched controls who received SOC treatment. https://t.co/Uso7Pkh1Kt
— JAMA Oncology (@JAMAOnc) February 15, 2023
https://brownneurosurgery.com/breakthrough-brain-cancer-vaccine/
Thank you for mentioning the PD1 trial:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=171752448
Believe carefully. This is the greatest and most powerful lesson that I have learned since arriving on Earth. Examine what you believe about yourself most importantly, and then believe carefully as you interact with the world.
