My post 538937 (targeted for Lykiri) contained a careless error that I would like to correct. The mPFS of the 99 placebos was 7.6 months (5/10/22 NYAS presentation) and Lykiri counted a total of 81 progression events of whom 48 occurred prior to 7.6 months from randomization and 33 thereafter. For 99 patients a 7.6 months mPFS would imply that about 49-50 patients have progressed before 7.6 months and 49-50 would have progressed thereafter. I therefore should have concluded that most or all of the 18 patients that Lykiri did not detect as having progressed did progress after 7.6 months on trial. That would mean that in addition to the 33 placebos detected by Lykiri as having progressed after 7.6 months, there were up to about 16 or 17 additional late progressors.
I erroneously wrote that perhaps 18 of the placebos never progressed and that is impossible since we know that all of the 64 crossovers progressed and according to Dr. LL most or all of the 35 permanent placebos had a rather short mOS and therefore even a shorter mPFS.
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