Friday, January 06, 2023 3:09:35 PM
Good points Captain.
As an aside, I think possibly the best thing about today’s presentation at Rhode Island hospital by participating neurosurgeons was the sincerity and objective reflection on the advance. Wherein, it requires a nuanced understanding of how “breakthrough” is defined.
A patient wants to know if they can “beat” this. Because DCVax-l in some cases can restore a functioning immune system, facilitate detection and destruction of the cancer and alertness to further cloaked attacks, it is the closest therapy patients have to “beat” GBM in some cases.
If approved, because of the requirements for combination therapies, as LP further explained recently, it can then be combined with other therapies like CSF1R, that remove tolerogenic cells from the tumor micro-environment, thus making recurrence far less likely. Aka: More cures.
LP really did recently try to subtly answer why combinations face more than just resource issues for trials. They also face dysfunctional regulators that can’t imagine two therapies might work together where only one by itself can on a limited basis. It’s as if the FDA would say iron makers can’t commercialize steel because carbon doesn’t make metal by itself.
Anyway, I digress.
As an aside, I think possibly the best thing about today’s presentation at Rhode Island hospital by participating neurosurgeons was the sincerity and objective reflection on the advance. Wherein, it requires a nuanced understanding of how “breakthrough” is defined.
A patient wants to know if they can “beat” this. Because DCVax-l in some cases can restore a functioning immune system, facilitate detection and destruction of the cancer and alertness to further cloaked attacks, it is the closest therapy patients have to “beat” GBM in some cases.
If approved, because of the requirements for combination therapies, as LP further explained recently, it can then be combined with other therapies like CSF1R, that remove tolerogenic cells from the tumor micro-environment, thus making recurrence far less likely. Aka: More cures.
LP really did recently try to subtly answer why combinations face more than just resource issues for trials. They also face dysfunctional regulators that can’t imagine two therapies might work together where only one by itself can on a limited basis. It’s as if the FDA would say iron makers can’t commercialize steel because carbon doesn’t make metal by itself.
Anyway, I digress.
Recent NWBO News
- Northwest Biotherapeutics Announces Establishment Of the Company's Own Dedicated Leukapheresis Clinic • PR Newswire (US) • 04/21/2026 01:30:00 PM
- Northwest Biotherapeutics Announces Establishment Of the Company's Own Dedicated Leukapheresis Clinic • PR Newswire (US) • 04/21/2026 01:30:00 PM
- Form EFFECT - Notice of Effectiveness • Edgar (US Regulatory) • 04/21/2026 04:15:08 AM
- Form POS AM - Post-Effective amendments for registration statement • Edgar (US Regulatory) • 04/16/2026 09:25:30 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 04/07/2026 04:30:50 PM
- Form NT 10-K - Notification of inability to timely file Form 10-K 405, 10-K, 10-KSB 405, 10-KSB, 10-KT, or 10-KT405 • Edgar (US Regulatory) • 03/31/2026 09:04:37 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 01/15/2026 10:06:20 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 01/02/2026 10:14:59 PM
- Form DEF 14A - Other definitive proxy statements • Edgar (US Regulatory) • 11/28/2025 09:43:27 PM
- Form 424B5 - Prospectus [Rule 424(b)(5)] • Edgar (US Regulatory) • 11/25/2025 10:23:07 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 11/20/2025 09:26:03 PM
- Form PRE 14A - Other preliminary proxy statements • Edgar (US Regulatory) • 11/19/2025 09:15:48 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 11/14/2025 09:44:21 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 10/31/2025 04:29:10 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 10/30/2025 08:40:05 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 10/24/2025 04:28:38 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 10/14/2025 06:22:26 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/14/2025 09:00:38 PM
- Form 424B5 - Prospectus [Rule 424(b)(5)] • Edgar (US Regulatory) • 07/01/2025 09:04:38 PM
