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Tuesday, December 13, 2022 6:39:02 PM
No, I am sure everyone knew what they were reviewing. Accusing JAMA and the reviewers of incompetence is a ridiculous notion.
It’s not relevant, and I don’t believe that every time Car-T trials are written up they mention their FULL halts, rather than partial halts. They do mention maybe if patients died. Which was the cause for Car-T trials being halted.
The reason seems obvious. Why randomize patients to placebo who are newly diagnosed and would get the best result and longer life from immediate receipt of DCVax-L if that would harm their prognosis and there would ultimately be an inadequate placebo arm because of crossover. It is unethical to do that when the reason for doing it, isn’t the outcome… a usable placebo arm. Obviously you don’t randomize anymore patients to placebo.
It’s not relevant, and I don’t believe that every time Car-T trials are written up they mention their FULL halts, rather than partial halts. They do mention maybe if patients died. Which was the cause for Car-T trials being halted.
The reason seems obvious. Why randomize patients to placebo who are newly diagnosed and would get the best result and longer life from immediate receipt of DCVax-L if that would harm their prognosis and there would ultimately be an inadequate placebo arm because of crossover. It is unethical to do that when the reason for doing it, isn’t the outcome… a usable placebo arm. Obviously you don’t randomize anymore patients to placebo.
I own NWBO. My posts on iHub are always posted expressly as just my humble opinion (IMHO) and none are advice, just my opinion. I am NOT a financial advisor, and it is assumed that everyone is responsible for their own due diligence.
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