Thursday, December 08, 2022 5:51:19 PM
LearningEveryTrade,
“The authors created a synthetic control...”. I don’t think so. As I recall a third party was called upon to compose contemporary ECA comparators. I think someone has been chewing on sour grapes for a while now and it shows. Too much innuendo not based strictly on scientific rigor and the idea of selection bias is NOT balanced out by the original attempt to find and enroll patients from the middle of the OS curve to work with in this trial. This meant excluding longer lived pseudoprogressors and early progressors so that the true benefit could be measured in a group from the middle. Dr. Stupp does not balance this out. Best wishes.
“The authors created a synthetic control...”. I don’t think so. As I recall a third party was called upon to compose contemporary ECA comparators. I think someone has been chewing on sour grapes for a while now and it shows. Too much innuendo not based strictly on scientific rigor and the idea of selection bias is NOT balanced out by the original attempt to find and enroll patients from the middle of the OS curve to work with in this trial. This meant excluding longer lived pseudoprogressors and early progressors so that the true benefit could be measured in a group from the middle. Dr. Stupp does not balance this out. Best wishes.
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