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Re: Jake2234 post# 2342

Wednesday, 11/23/2022 12:28:11 PM

Wednesday, November 23, 2022 12:28:11 PM

Post# of 2983

All we have seen is cellular potency.

That’s not entirely true. See slide #18 in the latest slide set (https://ir.enanta.com/static-files/0b9a9564-339c-4501-8c98-eab636846bf4 ):

– Good oral bioavailability (95% in rats) and long half-life (16 hours)

– Good target tissue distribution (e.g. lung to plasma AUC ratio >4)

Cellular assays don’t have lungs.

Also see the footnotes to slide #20.

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