Friday, November 18, 2022 9:22:32 AM
Ex, I've said previously that I thought the PFS endpoint failed, and it was at the core of the enrollment halt.
It's a subtle point but changing endpoints itself does not invalidate statistical conclusions. What matters is data dredging, which often is associated with changing endpoints but doesn't necessarily have to be. I got to think you, and other apparently smart people, understand that. So, I just don't get why you keep coming back to this point.
I've also said previously Stupp would support the trial and that we'd get a publication in a highly respected academic journal, like JAMA. I've also said that neurosurgeons not involved with the trial are very interested in the therapy (I gave one example, but I've had conversations with others).
A most important characteristic of the best investors is the ability to clearly judge new information, change your mind when the data conflicts with your prior (as I've also stated, I was short the stock once), and go big when it conforms.
Which way is the information trending in this case?
It's a subtle point but changing endpoints itself does not invalidate statistical conclusions. What matters is data dredging, which often is associated with changing endpoints but doesn't necessarily have to be. I got to think you, and other apparently smart people, understand that. So, I just don't get why you keep coming back to this point.
I've also said previously Stupp would support the trial and that we'd get a publication in a highly respected academic journal, like JAMA. I've also said that neurosurgeons not involved with the trial are very interested in the therapy (I gave one example, but I've had conversations with others).
A most important characteristic of the best investors is the ability to clearly judge new information, change your mind when the data conflicts with your prior (as I've also stated, I was short the stock once), and go big when it conforms.
Which way is the information trending in this case?
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