Tuesday, October 11, 2022 2:03:46 PM
The slides were totally positive and a scientific presentation. There was nothing there that would have caused the shares to crash. Total nonsense.
The presentation showed a 13% 5 year OS when based on earlier data investors were expecting more like 25%
They never said the important point that the endpoints were changed based on science learned from outside the trial and not from the trial. Further, they actually said the OS was changed from randomized ITT comp to ECA based on information from the trial.
They never presented the actual randomized OS data.,
The data showed ECA near total resections trended better than the treatment arm. The treatment arm had "intent for near total resection". No adjustment for "intent" vs actual is possible as they do not have patient level data.
They never actually presented the data that was adjusted for other predictive factors.
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