NorthWest Biotherapeutics Inc (NWBO)

[skitahoe]

Iron Mike,

If pseudoprogressors were found in the treatment group they shouldn't be removed from the trial, a determination of pseudoprogression is actually a sign the vaccine is working. If all in the treatment group were pseudoprogressing we'd probably be curing a lot of patients.

We really don't know at this point if our longest living patients were deemed to have progressed early in the trial, but actually had pseudoprogression, or not. Perhaps that's one of the things we'll learn once the Journal comes out.

I frankly don't know if today they can differentiate between progression and pseudoprogression without an invasive procedure, a needle biopsy may be sufficient, but I'm not certain of that. If it were adequate the question might be, do you make PFS part of the trial criteria or do you just stick with OS and allow the trial to take longer to achieve it.

Gary