NWBO's trial was an interventional trial NOT Adaptive. From clinicaltrials.gov: Study Type : Interventional (Clinical Trial) It is NOT okay to totally redo the trial protocol and SAP after the trial has been completed.
NWBO press release on the data lock made NO statement about any protocol change. 5 months later, NWBO announced they were changing the protocol but didn't reveal how. It wasn't until the May 10th, 2022 TLD presentation at NYAS that they publicly announced the NEW protocol with the post hoc data dredged recurrent GBM arm.
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