Dr. Musella is saying that 0% survived in the external control arms for 5 years. However the presented TLD from May 10th reported a 5 year survival of 5.7%or 5.8% in the external control arms. This is a very substantial difference and I am not sure I understand
The reason is that the trial data they compared to had almost no patient data reported for the full 5 years. About 20 is all.
Most GBM trials do not follow that long because for practical purposes the outcome is known by 3 years or so.
Of the 20 or so who were reported on at 5 years, none were alive. That is as opposed to the expected 1 being alive.
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