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Re: hope4patients post# 508155

Thursday, 08/25/2022 3:12:21 PM

Thursday, August 25, 2022 3:12:21 PM

Post# of 824080
DCVax-L was mentioned. Awesome. Thanks.

Autologous tumor lysate-based approaches may be preferable to shared antigens, as suggested by a study comparing parallel cohorts of autologous GBM tumor lysate-pulsed DCs versus GBM shared antigen-pulsed DCs98. This analysis found a correlation between decreased regulatory T cell (Treg) ratios and OS, including median survivals of 34 months versus 15 months favoring the autologous approach (DCVax-L), prompting an ongoing phase III trial (NCT00045968).

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