Wednesday, May 11, 2022 11:43:01 AM
how do you not get this? the control group was artificially strengthened because the weakest controls crossed over. by the end of the trial, only the controls that did not progress remained as controls. this is in essence cherry-picking the most resilient people to comprise the control group. and this is why that endpoint was found unviable, and why comparing blended to unblinded makes no sense.
by the end of the trial, any “controls” left were only those who are naturally hyper-resilient and lucky. this is no longer a control group.
a typical placebo patient would NOT experience what the remaining “controls” in this trial experienced. this is the whole reason for the endpoint change and ECA.
i’m redundant here but i’m not sure how else to explain it to you. usually you don’t go out of your way to lie but you keep hammering this point as if you don’t get it
by the end of the trial, any “controls” left were only those who are naturally hyper-resilient and lucky. this is no longer a control group.
a typical placebo patient would NOT experience what the remaining “controls” in this trial experienced. this is the whole reason for the endpoint change and ECA.
i’m redundant here but i’m not sure how else to explain it to you. usually you don’t go out of your way to lie but you keep hammering this point as if you don’t get it
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