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Re: Jonjones325 post# 359516

Friday, 05/06/2022 3:05:23 PM

Friday, May 06, 2022 3:05:23 PM

Post# of 518935
I think we need to add a by how much A2-73 might beat SOC and for what proportion of the inclusion/exclusion criteria patients.

First let’s assume that the TLR is in fact stat sig positive.

Then assume that in the 50mg target dose cohort about 20% of patients remain at least stable over 48 weeks. That in my estimate would beat SOC almost regardless the of the A2-73 response in the rest the of dosed patients.

For that to occur there is probably no more than a 50/50 chance, which are pretty good odds considering the reward.

Anything beyond that is a big bonus.
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