Crispr Therapeutics AG (CRSP)

[jondoeuk]

As for edits, knockouts (in addition to CD70) could include TET2 [1], CD95 [2], TGFBR2 [3], regnase-1 [4], and/or SOCS1 [5]. Also, the knock-in of (inducible) IL-12 [6-8].

Refs:
1 https://www.nature.com/articles/s41586-018-0178-z
2 https://www.jci.org/articles/view/121491
3 https://insight.jci.org/articles/view/133977
4 https://www.nature.com/articles/s41586-019-1821-z
5 https://www.science.org/doi/10.1126/sciimmunol.abe8219
6 https://aacrjournals.org/cancerres/article/71/17/5697/568127/IL-12-Release-by-Engineered-T-Cells-Expressing
7 https://www.tandfonline.com/doi/full/10.4161/2162402X.2014.994446
8 https://www.cell.com/molecular-therapy-family/oncolytics/fulltext/S2372-7705(17)30052-9