Anavex Life Sciences Corp (AVXL)

[falconer66a]

Well, in both humans and C. elegans.

We describe, at the molecular level, for the first time, that pharmacological Sig-1R activation a) enhances the autophagic flux in human cells and in Caenorhabditis elegans....

George, thank you for posting this paper, where the researchers used Anavex 2-73 (blarcamesine) to activate sigma-1 receptors in the roundworm C. elegans, to assess the resulting successful clearance of protein wastes.

Dr. Missling surely has this information, and knows, as I contended, that blarcamesine-induced or -restored autophagy yields significant therapeutic outcomes. Of course, this is just a small, uncomplicated roundworm (which is a major study organism for aging studies). But, as the paper states, blarcamesine facilitates the same process in higher organisms, including humans.

Understand, one of the major deficiencies of aging is the reduced ability of cells, tissues, and organs to clear accumulated cellular wastes, poorly functioning autophagy. In youth and early adulthood, chemical wastes are efficiently cleared; they can't cause problems. But, with age, autophagy becomes less effective; chemical wastes accumulate and disrupt various processes; especially in neurons.

This is one reason intermittent fasting is healthful. When the body goes for periods without food, organ processes can be re-directed to clear wastes.